Pathogenetic characteristics of the hormonal profile in rats subjected to restraint stress of different duration

The aim of the work is to ascertain character changes in hormonal profile (concentrations corticosterone, insulin, and adrenocorticotropic hormone) conjunction with metabolic alterations elevated blood pressure, which are induced rats by restraint stress at 6th, 15th 21st weeks environmental space restriction.
 Materials methods. A total 55 normotensive male Wistar rats, aged 6–10 months, were assigned into 4 experimental groups (1 – intact control (10 rats); 2, 3 (15 each exposed restricted allowance)). All animals subjected pressure (BP), glucose level body weight measurements twice: stage forming weeks. Plasma hormone concentrations (insulin, ACTH) examined immunoenzymatic method using commercial kits (Monobind, USA).
 Results. was significantly reduced 20.72 % after 6 allowance restriction, it restored baselines week exceeded values 26.1 week. BP levels showed an increasing trend, a dynamic increase systolic 7 %, 17 26 detected, respectively, as well diastolic from 21.4 37.0 respectively. Glucose concentration within euglycemic range. Changes ACTH more than 50 decrease insulin 34 6th subsequent twofold (at 15) further As for peak 3.77 times noticed week, followed restoration normative week.
 Conclusions. Even minor unremarkable continuously acting stressors, cannot be coped, become important triggers carbohydrate metabolism persistent manifest first hypoinsulinemia, ACTH, constant corticosterone. Long-term exposure contributes transient “peak” corticosterone level, significant sustained ACTH. Multidirectional studied hormones occur amidst gradual stable glycemia.